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In a 24-week open-label Phase I/II clinical trial (Clinicaltrials.gov Identifier: NCT00779194) in patients with active SLE, sirolimus treatment increased the proportion of circulating Foxp3+ Tregs, suppressed IL-17 and IL-4 secretion, and facilitated glucocorticoid tapering (mean prednisolone dose reduced from 23.7 mg to 7.2 mg daily) (236)

10.1007/978-3-319-30567-7_3 7 BibiR.JahanS.AfsarT.AlmajwalA.HammadehM

Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour

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Maternal food consumption during pregnancy and asthma, respiratory and atopic symptoms in 5-year-old children