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We now recognize that, even for T-B + NK- SCID phenotypes, although full myeloid chimerism is not necessary for cure, a degree of myeloid engraftment will enable B-lymphocyte reconstitution and long-term thymopoiesis ( Key concepts for SCID: Newborn screening is now established in many countries Prevention of infection prior to definitive treatment affects outcome Conditioning prior to HSCT is recommended for all, to ensure good long-term outcomes Emerging IEI Patients with undefined T cell deficiencies historically had a worse outcome which maybe because transplant only took place as a last resort ( p = 0.006

DOI:10.1016/j.redox.2022.102286 113

The mitochondrial stress responses: the Dr