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Rarely, people with a seizure disorder may experience more frequent seizures, and severe allergic reactions have been reported

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AMPK additionally augments reverse cholesterol transport in atherosclerosis and polarizes macrophages to an M2 phenotype (404), which are associated with plaque stability and regression (406)

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'Leaving' groups During its reaction with DNA the dichloro groups of cisplatin are displaced or substituted but the two ammine groups remain intact, leading to a convention to refer to the groups within platinum cancer drugs that are displaced as 'leaving groups' (and those that remain as stable or carrier ligands)