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Am J Med Genet B Neuropsychiatr Genet 141 : 487498

Critically, two-thirds of depression patients fail to achieve remission on first-line antidepressants precisely the population Caplyta now targets as an adjunctive therapy

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(Chapman & Hall, 1982)

One of the key regulators of oxidative stress in diabetes is thioredoxin-interacting protein (TXNIP), which acts as an endogenous inhibitor of the antioxidant thioredoxin (TRX)