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The scalp was anaesthetised with lidocaine beforehand

Molecules 25(24):5980 Shokri Y et al (2020) Importance of paraoxonase 1 (PON1) as an antioxidant and antiatherogenic enzyme in the cardiovascular complications of type 2 diabetes: genotypic and phenotypic evaluation

Serious side effects of B12 are injections rare but should be discussed with your provider before starting treatment

(2001) Journal of Clinical Pharmacology n=34 Pharmacokinetic study establishing AOD 9604 peak plasma levels, elimination half-life, and subcutaneous bioavailability

MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited human safety data Animal studies report wide therapeutic window Known interactions Methyl-donor depletion theoretical with chronic dosing (NNMT methylates nicotinamide using SAM) Contraindications Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Not FDA-approved