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Week by week expectations Understanding typical progression helps set realistic expectations and identify whether your protocol needs adjustment

Curr Med Sci 40

Now Im not talking below average B12, or suboptimal B12 levels, or even whats clinically called B12 depletion, where your levels place you at high risk for deficiencybut actual bonafide vitamin deficiency, meaning that your levels are so low your biochemistry is screwed up

Buffering by proteins accounts for two-thirds of the buffering power of the blood and most of the buffering within cells

This triple mechanism distinguishes it from dual-agonist peptides like tirzepatide (GLP-1/GIP) and single-agonist compounds like semaglutide (GLP-1 only), making it the most broadly acting incretin-class compound currently under clinical investigation