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Previous research has demonstrated that supplementing probiotics helps maintain the balance of gut microbiota in the host, while also increasing the number of beneficial bacteria and reducing the colonization of harmful bacteria in the intestinal tract ( Bacillus velezensis isolated from Tibetan yaks can enhance the gut microbiota of mice ( Bacillus velezensis TS5 decreased the relative abundance of potential harmful bacteria such as Helicobacter , Unspecified_Desulfovibrionaceae , and Colidextribacter in the cecum and improved the composition of the mices cecum microbiota to a certain extent

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While the efficacy of PARP inhibitors has been evaluated in several studies in pancreatic cancer, there are hardly any reported in CCA and data from two first-line umbrella studies using veliparib (NCT01282333) and rucaparib (NCT03337087) in combination with chemotherapy are awaited

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Oncotarget 8(39):66680 Ghosh A, Banerjee T, Bhandary S, Surolia A (2014) Formulation of nanotized curcumin and demonstration of its antimalarial efficacy