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Available online at: (Accessed February 13, 2025)

TRIUMPH-4 is the first pivotal trial to confirm that the weight-loss signal seen in Phase 2 scales with longer exposure and higher doses, and it adds several new secondary findings that reshape how researchers think about 9 mg and 12 mg as working doses

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Elevated homocysteine has been associated with skin changes including hyperpigmentation, and some research connects poor methylation status to inflammatory skin conditions