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[107]aimed to evaluate the impact of inhibiting autophagy signaling via 3-methyladenine (3-MA) on cardiac pathological effects and dysfunction mediated by chronic nicotine exposure

Indeed, a number of studies have reported anti-inflammatory effects of the MedDiet as a whole including reduced c-reactive protein, TNF- and IL-6, which appear, in part, to be related to altered methylation of inflammation-related genes (Reference Arpn, Riezu-Boj and Milagro74) and down-regulation of the NF-B pathway (Reference Perez-Martinez, Lopez-Miranda and Blanco-Colio75)