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Availability of data and materials No datasets were generated or analyzed during the current study

& Eckert, R

These findings further ruled out mitochondrial damage to be the source of GSH depletion-induced oxidative stress

First, a toxic loop involving ferroptosis, -synuclein, and neuromelanin exists in the PD microenvironment, yet this study has not clarified the bidirectional regulation between ferroptosis and -synuclein oligomersspecifically, whether oligomers disrupt LIP homeostasis to trigger ferroptosis, or how lipid peroxidation products from ferroptosis accelerate protein aggregation