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doi: 10.1016/j.foodcont.2019.106886 363 MoroLGPolaquiniCRKopaczMTorrezanGSAyussoGMDilarriGet al

Recent studies have illustrated various resistance pathways, including mutations affecting drug targets and efflux pump mechanisms, as well as the ability to manipulate host immune responses to evade clearance (Xie et al., 2025)

In addition, although both receptors facilitate chemoresistance to the selective estrogen receptor modulator (SERM) tamoxifen in breast cancer, resistance to tamoxifen is characterized by decreased expression of IGF-1R and increased EGFR expression, and more surprisingly, no detectable difference was found in EGFR expression between breast cancer cells resistant and sensitive to tamoxifen when measured with cytometry (79)

Derivatives include the brain, spinal cord, posterior pituitary, pineal gland, and the retina

Pain could be present, but also may not be