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doi: 10.1038/s41598-022-18195-8

Review of Studies Examining How Metformin Affects the Status of Specific Micronutrients and the Microbiome Vitamin B1 Vitamin B1 (thiamine) acts as a coenzyme in neurotransmission and low levels of this nutrient may have a role in the development of certain diabetic complications

Post-marketing surveillance and case reports have documented isolated instances of patients reporting muscle pain, cramping, or weakness while taking GLP-1 medications, though establishing a direct causal relationship remains challenging

Evidence of administering Vitamin B12 injections suggests that patients report a wealth of benefits from treatment

The importance of pharmacokinetics and pharmacodynamics in patient care thus rests upon the improvement in therapeutic benefit and reduction in toxicity that can be achieved by application of these principles