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In a mouse model of stroke, intracerebroventricular sodium selenate treatment elevates GPX4 levels by activating transcription factors activating enhancer binding protein 2 and specificity protein 1, while also providing protection against excitotoxicity and endoplasmic reticulum stress-induced cell death independent of GPX4 (102)

( a - d ) The proportion of participants receiving semaglutide or placebo who reported nausea (a), diarrhea (b), constipation (c), or vomiting (d) events classed as mild, moderate, or severe over the course of the treatment period

3 Diabetic kidney disease (DKD) affects 3040% of people with diabetes globally, with higher rates in type 1 diabetes (~40% after 20 years) and significant regional variationsaccounting for 4050% of end-stage renal disease (ESRD) cases in developed countries

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