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Erythrocytes play a crucial role in the regulation of eNOS-derived nitric oxide (NO) bioavailability, acting as scavengers of this critical vasodilator with an effect on vascular tone and blood flow [45]

Concomitantly, expanded adipose tissue synthesizes and secretes huge amounts of cytokines and chemokines, collectively defined adipochemokines or adipokines, such as leptin, that promote infiltration of adipose tissue by macrophages with subsequent overproduction of RO(N)S and inflammatory cytokines, leading to adipose tissue inflammation (21, 22)

The brain, compared with other organs, is particularly prone to lipid peroxidation due to the abundance of unsaturated fats and redox-active transition metals

Merad-Boudia M, Nicole A, Santiard-Baron D, Saill C, Ceballos-Picot I

While DFP has demonstrated the capacity to reduce mitochondrial iron overload and mitigate oxidative stress in preclinical models, its clinical application highlights a critical challenge