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While both therapies can provide significant benefits, individual responses vary

10.1038/s41477-018-0328-1 19 CuiL.PeriniG.MinopoliA.AugelloA.De SpiritoM.PalmieriV.et al (2024)

The term "double-stranded RNA", "duplex RNA" or "RNA duplex" refers to RNA having two strands and at least one double-stranded region, and includes RNA molecules having at least one gap, nick, bulge, loop, and/or bubble within a double-stranded region or between two adjacent double-stranded regions

Recent studies further emphasize that the biosafety and efficacy of curcumin nanoformulations are governed by the physicochemical properties of their carrier matricesparticularly particle size, surface charge, and solubility (Pillarisetti et al., 2017