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Similar to other TOPO1i payloads like DXd and SN-38, ED04 is expected to possess adequate membrane permeability to facilitate a bystander effect, which is likely contributing to the encouraging efficacy observed in HER2-heterogeneous breast cancer populations

Funding All authors declare no funding for this contribution

This is contrary to Mohan et al.s earlier report that suggested WA might inhibit NFB activity by impairing IB degradation and ubiquitination [98]

A total of 112 simulations were performed to study the impact of seven zonation hypotheses across a spectrum of APAP doses

Those surviving from this group performed more poorly than later-onset presentations