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Abbreviations TBK1: TANK-binding kinase 1 NQO1: NAD(P)H: quinone-oxidoreductase-1 IKK: IkappaB kinase NF-B: Nuclear Factor Kappa B RIG-I: Retinoic acid-inducible gene I MDA5: Melanoma differentiation-associated protein 5 cGAS: Cyclic guanosine monophosphateadenosine monophosphate IRF3: Interferon regulatory factor 3 IFN: Interferon IRF7: Interferon regulatory factor 7 ROS: Reactive oxygen species BSL-2: Biosafety Level 2 BSL-3: Biosafety Level 3 VSV-GFP: Green fluorescent protein tagged vesicular stomatitis virus HSV-GFP: Green fluorescent protein tagged herpes simplex virus ELISA: Enzyme-linked immunosorbent assay DMEM: Dulbeccos modified Eagle medium RPMI: Roswell Park Memorial Institute medium PCR: Polymerase chain reaction BMDM: Bone marrow-derived macrophage mGM-CSF: Mouse granulocyte macrophage colony-stimulating factor FBS: Fetal bovine serum MDM: Monocyte-derived macrophages TK-Renilla: Thymidine kinase promoter-renilla RIPA: Radio-immunoprecipitation assay BALF: Bronchoalveolar lavage fluid STAT1: Signal transducer and activator of transcription 1 KD: Kinase domain ULD: Ubiquitin-like domain CC1: Coiled-coiled domain 1 CC2: Coiled-coiled domain 2 PTM: Post-translational modification GSK3: Glycogen synthase kinase-3 beta References Runde AP, Mack R, SJ PB, Zhang J