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Pharmacological inhibition of ATM (e.g., KU-55933) reduces mitochondrial transcription factor A (TFAM) expression in melanoma and breast cancer cells, promotes mtDNA leakage into the cytoplasm, activates the cGAS-STING signaling pathway and downstream cytokine production, and enhances lymphocyte infiltration into the TME, resulting in anti-tumor therapeutic effects (80)

In: Heilman KM, Valenstein E (eds) Clinical neuropsychology, vol 5

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They act as signaling molecules in the body, telling tissues and cells what to do