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Optimizing staple type and number significantly mitigates off-target activity To explore the effect of staple number and type on peptide properties, we made a series of peptides with alternative crosslinks

189,190,191 Activation of GLP-1R leads to the production of cAMP (cyclic Adenosine Monophosphate), which is achieved by activating Adenylyl Cyclase (AC)

Similarly, the R2.1 variant uses a negatively charged Asp153 to specifically recognize the positively charged amine group of R -THIQ (3.7 in distance

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Inhibition of aflatoxin B1 biosynthesis in Aspergillus flavus by anthocyanidins and related flavonoids