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Both families of enzymes use NADP + as cofactors to perform reversible reactions, where isocitrate is oxidatively decarboxylated to alpha-ketoglutarate and generates one NADPH per reaction

EGCG can suppress EAE by lowering neuronal damage and brain inflammation

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-Ketoglutarate-Dependent dioxygenases

10.1002/ana.22528 122

The first 50 principal components were used to cluster the cells based on the shared nearest neighbours (SNN) algorithm and visualised in two dimensions by uniform manifold approximation and projection (UMAP)