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In graft-versus-host disease (GVHD) models, inflammation-induced loss of microbial FXR antagonists or pharmacological FXR agonism exacerbated disease

Elevated levels of ROS and iron in haematopoietic cells lacking the H-ferritin gene lead to a reduction in T-cell populations ( Figure 2 ) (112)

2023;9:e19605

Perhaps most frustrating is post-exertional malaise (PEM), a hallmark symptom where even minor physical or cognitive exertion triggers a severe, delayed crash in baseline functioning

Transforming growth factor-1 (TGF-1) can induce the EMT phenotype in melanoma cells and upregulate the levels of GPX4 and SLC7A11, while gambogenic acid, a xanthone derived from traditional Chinese medicine Gamboge, can promote ferroptosis by inhibiting the SLC7A11/GPX4 pathway in melanoma cells stimulated by TGF-1