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2022;18:e2203659

Seemingly in opposition to the theory that the diminished GH secretion of older age is a net detriment are observations that animal models of congenital GH deficiency have remarkably increased lifespan, and that humans with congenital GH deficiency may have decreased rates of age-related diseases such as diabetes and cancer

L-methylfolate supplementation effectively restores impaired endothelial-dependent vasodilation and enhances endothelial health by converting Hcy to methionine, regardless of dietary deficiencies or genetic polymorphisms that inhibit folic acid processing or L-methylfolate synthesis [31, 104, 108,109,110,111]

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10.1007/BF01970670 29 ShiJ.ChangX.ZouH.GuJ.YuanY.LiuX.et al (2021)