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(iii) MDA is not generated exclusively through lipid peroxidation

31, 32B, E) and CD4 + T cells (Supplementary Figs

In addition, inhibition of Dhodh in tumor cells can reduce CDP-choline levels and the phosphatidylcholine (PC) synthesis of CDP-choline-dependent Kennedy pathway, promote CD8 + T cell infiltration and enhance the antitumor activity of PD-1 blockade in female mouse models [235]

Trial registration This trial has been registered with ClinicalTrials.gov, number NCT 01476007, and under EUDRACT number 2010-024129-20

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