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These signaling molecules and transcription factors are involved in both the hyper-inflammatory phase (elevated HIF-/low Sirtuins) and the second immune-tolerant, recovery phase of sepsis (elevated Sirtuins/low HIF-)

In the liver, continuous accumulation of Cu + activates increasing levels of protection (Figure 3)

doi: 10.1016/j.foodchem.2015.01.004 197 SabzevariS.HofmanJ

Pediatrics 105 , e46e46 (2000)

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