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Etiology and Risk Factors The etiology of IPF is unknown, although it is probably due to the effect of various factors in genetically predisposed subjects.8 Genetic Factors The most clinically relevant genetic alterations are: mutations in the genes that maintain the length of the telomeres (TERT, TERC), which are more common in the familial forms, in the surfactant protein C gene and in the mucin 5B promoter region (MUC5B)