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Introduction# HGH 191AA and HGH Fragment 176-191 share a direct structural relationship: the fragment is literally the last 16 amino acids of the full 191-amino acid growth hormone protein

Bioorg Med Chem Lett 28:26822687

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Gene-level modulation: Pickart & Margolina 2018 documented activity across ~4,000 human genes, with fibroblast expression patterns shifting closer to younger cells