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It may contribute to a more youthful physiological state, extending longevity and lowering the risk of age-related disorders, by perhaps slowing cellular senescence, or the aging of cells

Diarrhoea may occur in some individuals, particularly with higher-dose supplements

Nicotinamide N -methyltransferase (NNMT) serves as a crucial link between cellular metabolism and epigenetics by catalyzing nicotinamide methylation using the universal methyl donor S-adenosyl-L-methionine