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This observation aligns with the foundational heterogeneity established by Kusumbe et al

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GTPases are activated by metabolites formed from the mevalonate pathway, thus by inhibiting HMGCR, statins inhibit not only the synthesis of cholesterol, but also the other metabolites produced by the pathway [85,86,87]

Tissue Cell (2023) 83:102116

2-deoxy-D-glucose, a competitive inhibitor of glycolysis, has been shown in murine models of allergic asthma to prevent the pathological glycolytic shift in AMs [133]