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We studied the potential for EHBD injury prevention and repair using NAC, a precursor of glutathione, which is listed under the World Health Organizations List of Essential Medicines 8 , and its known safety profile makes it an attractive agent for the treatment of a broad scope of diseases

Furthermore, among the ORF3a homologs from -CoV (HCoV-229E), -CoV (SARS-CoV-2, SARS-CoV, and Middle East respiratory syndrome coronavirus (MERS-CoV)), and -CoV (IBV), SARS-CoV-2 ORF3a uniquely inhibited autophagy (Supplementary Fig