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Between 1990 and 2016, the annual incidence increased by 3.6% ( Following trauma, around one quarter of patients will develop a trauma-induced coagulopathy (TIC), defined as a prothrombin ratio of 1.2 or higher and an activated partial thromboplastin time greater than 60 ( Pathophysiology of TBI-induced coagulopathy The pathophysiology behind the coagulopathy of TBI is complex

The environmental estrogen, nonylphenol, activates the constitutive androstane receptor

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However, the limited sample size (n = 3 per group) reduces the reliability of these findings (Mohebali et al., 2018)