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The clinical trial protocol used a gradual dose escalation to minimize GI side effects: Most users inject into the abdominal area, rotating sites with each injection

However, if symptoms are severe, persistent, or associated with breathing difficulty, widespread rash, or swelling of the face or throat, immediate medical attention is required as these may indicate an allergic reaction

Honda, Y., Takaomi Kessoku, Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., Wataru Tomeno, Kento Imajo, Fujita, K., Yoneda, M., Kataoka, K., Masataka Taguri, Yamanaka, T., Seko, Y., Tanaka, S., Saito, S., Ono, M., Satoshi Oeda, Eguchi, Y., & Wataru Aoi

Gastroenterology 133 , 507516 (2007)

Recently, Lao et al