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Description

Several cell types are particularly sensitive to reduced frataxin, particularly neurons within the central and peripheral nervous systems (CNS and PNS), hence the majority of FRDA sufferers experience progressive neurodegeneration during their lifetime

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Contributed by Lananh Nguyen, MD and Jeffrey Kant, MD, PhD

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Treatment with BAY60-6583 (an A2BR agonist) exacerbates gastric ulceration in rats, while PSB1115 (an A2BR antagonist) has the opposite effect

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and how this encounter is spatially and temporally controlled

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