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Nicotinamide phosphoribosyltransferase is required for the calorie restriction-mediated improvements in oxidative stress, mitochondrial biogenesis, and metabolic adaptation

We're also seeing an increased interest in the long-term effects of NNMT inhibition

By the mid-2010s, 5-Amino-1MQ emerged as one of the compounds used in experimental NNMT-related research investigating metabolic signalling and enzyme regulation