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These circulating factors can elicit responses in CNS-resident immune cells

109 Hypoxic stimulation upregulates VEGF, establishing an angiogenesis-osteogenesis coupling mechanism that concurrently promotes bone vascularization and potentiates bone formation

Source: May 20th is Clinical Trials Day

This process helps regulate blood sugar levels, reducing the reliance on excessive insulin production and decreasing insulin resistance (Yaribeygi et al., 2019)