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41,252 At the same time, viral particles infect neighboring young cells through paracrine or humoral diffusion, spreading the senescence phenotype to the whole body through the mechanism of contagious aging, resulting in a cascade of amplification effects

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Some studies [55, 56, 57] showed that each catalase tetramer has four tightly bound NADPH molecules that appear to be important only to protect the enzyme against inactivation by its own substrate (H 2 O 2 ), and are not essential for its catalytic activity