slc25a39 is necessary for mitochondrial glutathione import in mammalian cells

slc25a39 is necessary for mitochondrial glutathione import in mammalian cells protein levels are directly regulated by cellular GSH Mitochondrial GSH import is mediated

Name: slc25a39 is necessary for mitochondrial glutathione import in mammalian cells protein levels are directly regulated by cellular GSH Mitochondrial GSH import is mediated
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Mitochondrial GSH import is mediated by SLC25A39 a, Volcano plots Download Scientific Diagram Autoregulatory control of mitochondrial glutathione homeostasis Science Up regulated SLC25A39 promotes cell growth and metastasis via regulating ROS production in colorectal cancer Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS Nature Communications Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis bioRxiv

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The hypothesis has expanded to include vascular dysfunction, oxidative stress, microglial activation, and impaired proteolysis (Roda et al., 2022)

An earlier study (Sikiric et al., 1993) confirmed the hepatoprotective effect using different liver injury models

[DOI] [PubMed] [Google Scholar] 64.Lobo V., Patil A., Phatak A., Chandra N

Occurrence Moreover, glutathione occurs in raw meat, fruit, and vegetables, while glutamine occurs in beef, pork, dairy products, raw spinach, raw parsley, and cabbage