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PD is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta and the presence of aggregated, intracellular inclusions containing -synuclein, termed Lewy bodies [199]

Capmatinib is a class Ib small molecule inhibitor against c-MET that has been used in clinical trials

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Taken together, these data suggest that inhibiting HGF does not alter the number of functional synapses in vehicle treated neurons but attenuates the effects of HGF and Dihexa on synaptogenesis by decreasing the number of postsynaptic spines