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DSF inhibits proteasome activation (Voorhees and Orlowski, 2006), leading to the accumulation of misfolded proteins and potentially toxic protein aggregates ( 8.4 Downregulation of PLK1 expression Polo-like kinase 1 (PLK1), which is highly expressed in tumor cells, is a key serine/threonine kinase involved in many important cell cycle functions such as mitotic entry, centrosome maturation, cell cycle progression, and cytoplasmic division (Triscott et al., 2012)

Gannon, M

Retrieved February 5, 2019

Recommended Use: Take 2 capsules per day or as directed by your health-care practitioner

Syme CD, Nadal RC, Rigby SEJ, Viles JH (2004) Copper binding to the amyloid-beta (Abeta) peptide associated with alzheimers disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(128): insights from a range of complementary spectroscopic techniques