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Tirzepatide injections frequently cause localized itching at the injection site, usually resolving within a few hours to days as the initial inflammatory response subsides

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This pattern is consistent with what researchers would expect for a compound where placebo effects, injury variability, and administration differences all contribute noise to self-reported outcomes

Jaundice: Yellowing of the skin and eyes, known as jaundice, is a severe symptom of liver failure resulting from acetaminophen toxicity