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The hydrolysis of extracellular Gln by the GGT from gastric helicobacters can cause a depletion of this conditionally essential amino acid in the gastric juice of an infected host, which may eventually lead to epithelial cell damage and immunological dysfunction 16,18,20

Biosynthesis of H 2 S H 2 S can be generated in mammalian physiology via dedicated endogenous enzymatic systems, gut microbiota metabolism and the breakdown of dietary polysulphide sources such as, for example, garlic and onion (reviewed e.g

In particular, genes reflecting an oxidative stress response, for example SLC7A11 and HMOX1 , were profoundly upregulated upon GPX4 perturbation in cells treated with giredestrant, and only minimally in DMSO treated cells

Yanan Li, [email protected] These authors have contributed equally to this work This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

PubMed, Modica, Joseph S., et al