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217 Moreover, metagenomic analysis of the gut microbiome in PD patients has detected a reduced capacity to generate dopamine precursors, particularly tyrosine

360 Additionally, studies have shown that the expression of PGC-1-responsive genes is downregulated in the brains of PD patients, possibly due to hypermethylation of PGC-1 transcriptional elements, leading to bioenergetic dysregulation

Given the existence of the specific OCTN1 transporter and the selective accumulation in neural and metabolically active tissues, this raises the question of whether the Western decline in mushroom consumption compared to traditional cultures in Asia, where mushrooms have been a staple food for thousands of years may contribute to a chronic undersupply that could correlate with the rise of neurodegenerative disease

10.1016/j.eurpsy.2017.10.012 136 WuD.WangH.TengT.DuanS.JiA.LiY

Many patients feel more confident after seeing positive results