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Nature Reviews Immunology, 5, 1-15

Toxicity Is Rare, Not Impossible: A

Moreover, several studies demonstrated that proIGF-1s remained unprocessed in cultured cells, whether endogenously expressed IGF-1 isoforms (HepG2, K562 and HeLa cells 8,9 ) or that were exogenously transfected with IGF-1 isoforms (HEK293 cells 7 )

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