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Possibly a specialized lymphoid tissue, such as that of the thymus which is most active in embryonic and early independent life and decays soon after, is engaged in this function' (Jerne, Nov 1955)

The production of SAMe plummets, meaning the body can no longer efficiently synthesize the myelin needed to protect peripheral nerves, leading to tingling, numbness, and neuropathic pain

Endocrinology 140:53915401 Glowinski J, Kemel ML, Desban M, Gauchy C, Lavielle S, Chassaing G, Beaujouan JC, Tremblay L (1993) Distinct presynaptic control of dopamine release in striosomal- and matrix-enriched areas of the rat striatum by selective agonists of NK1, NK2 and NK3 tachykinin receptors

Tapering long-term opioid therapy in chronic noncancer pain: evidence and recommendations for everyday practice