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Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins

Toxic doses in research have been measured at 300-3,750 times higher than therapeutic ranges, providing substantial safety margins

10.1038/s41591-022-01840-0 121

*Correspondence: Joanne E

In support of this view, we found that SIRT7-2E almost abolished the AMPK-mediated SKP2 phosphorylation at S256, while the effect on the SKP2-S256A mutant was less marked (Fig