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doi: 10.1056/NEJMoa2204705 177 MindellJ

Activated LINE elements generate abundant RNADNA hybrids, which are recognized as foreign nucleic acid signals by the cGAS-STING pathway, inducing immune responses and amplifying inflammatory signals closely linked to neuroinflammation in AD

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In humans, Menkes syndrome is a main manifestation of copper deficiency and causes serious neurological disorders (Danks et al., 1972

TRPM2-deficient microglia exhibited increased LC3A/B-II levels, indicative of autophagosome formation, and decreased SQSTM1/p62 levels, suggesting enhanced autophagic flux