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Am J Hum Genet 33 (1):1124 Zhao N, Liu CC, Qiao W, Bu G (2018) Apolipoprotein E, receptors, and modulation of Alzheimers disease

Mitochondrial membrane potential (m), a key indicator of mitochondrial integrity, becomes depolarized under oxidative assault, impairing ATP synthesis via oxidative phosphorylation (OXPHOS)

These ranges are for planning only

While clinical trials for NASH are ongoing and activation of AMPK by PXL770 in mice improves atherosclerotic outcome (403, 413, 414), whether these results extend to human atherosclerotic patients has yet to be explored