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The importance of proteases in the pathogenesis of IEB dysfunction described in IBS is further supported by the evidence that transfer of fecal supernatants from patients with diarrhea-predominant IBS evoked increased mucosal permeability in mice and mucosal factors obtained from IBS evoked IEB dysfunction and TJ disruption in isolated epithelial monolayers (228)

The pathophysiology underlying the vast majority of IPD patients is complex and to date, only partially understood (Blauwendraat et al., Supplementary Table 1)

Introduction Chronic obstructive pulmonary disease (COPD) is a chronic airway disorder manifested by a persistent airflow obstruction and pulmonary parenchymal destruction, characterized by chronic airway inflammation and emphysema and finally causing respiratory failure (Wang et al., 2016a

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