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Cross-disease comparisons suggest that these modules recur across different organ niches, but their net effects are markedly context-dependent and are jointly regulated by disease stage (acute inflammation versus chronic tissue remodeling), tissue compartment (peripheral blood versus lesional tissue), as well as the spectrum of stimuli and therapeutic exposure, thereby leading to inconsistent directional outcomes of the same pathway across different models and time windows

GST is catalyzing S-conjugation reaction between the thiol group of tri-peptide glutathione, GSH (Glu-Cys-Gly) and electrophilic moiety in the hydrophobic and toxic substrates [14]

For some water-soluble nutrients, especially vitamin C, this can produce blood levels that oral dosing cannot reach

Fontana L, Kennedy BK, Longo VD, Seals D, Melov S

10.1093/bioinformatics/bts174 Bioinformatics 78 PhamV