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A meta-analysis of randomized, controlled trials demonstrated an approximate 2-fold increase in hospitalizations for heart failure among nonselective- and COX-2 selective NSAID-treated patients compared to placebo (5)

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You will see it stated confidently in a lot of places that the body adapts after 4 to 6 weeks, tolerance builds, and the effect fades, so you have to cycle. It sounds authoritative

Conclusion Two thirds of an unselected group of ME/CFS patients treated for 3 months with vitamin B12 nasal drops had a favorable outcome in objective measures and subjective patient reported outcome, which were associated with a significant increase in serum vitamin B12 levels