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The approach taken in these studies provides a paradigm that may be of importance in elucidation of causes of hyperbilirubinemia in all patients, including substance abusers who are at risk for exposure to many potential hepatotoxic agents and viruses

(2017) 170:64963.e13

Intracellular proteolytic processing of precursor polypeptides is an essential step in the maturation of many proteins such as plasma proteins, hormones, neuropeptides, and growth factors 331

This extensive distribution, combined with rapid plasma clearance, suggests tissue binding or cellular uptake contributes to the peptide's pharmacological effects

Diarrhea is also a common symptom in digestive disorders like food intolerances, food allergies, irritable bowel syndrome (IBS-D), ulcerative colitis and Crohns disease (inflammatory bowel disease), and small intestinal bacterial overgrowth (SIBO)